Your comment will be removed, and you may be banned. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. My dog takes Incurin 1mg tablets. 59, 673-679. WebProin and Incurin can be used in tandem if problems persist but with Bella it wasn't necessary. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. JAVMA. A place where you can ask veterinary medicine related questions and get advice from veterinary professionals. Freedom of Information Summary. prnpharmacal.com/products/urinary-health/proin-er. WebProin vs. Proin ER Comparison | PetMeds FREE Standard Shipping When You Spend $49+ EXTRA 40% OFF Use code NEW40 in cart (up to $40 discount) 2% Back on all Urol Int. Accessed October 2020. Acquired urethral sphincter mechanism incompetence usually (but not always) follows spaying in the bitch and, occasionally, castration in male dogs. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. I will never use Proin in a hound. I felt so bad for her because she knew that she had done something bad - peeing inside - but didn't remember doing it. The active ingredient Phenylpropanolamine is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. The agonistic and antagonistic actions of estriol. Proin chewable tablets. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. The pathophysiology of male urethral sphincter mechanism incompetence is poorly understood, making rational treatment difficult. 11. It has a different mechanism of action than Proin but tries to achieve the same end result in the same tissue. Generally, therapy with phenylpropanolamine is safe; however, routine blood pressure monitoring should be performed to screen for hypertension, and special consideration should be taken before prescribing phenylpropanolamine to animals with behavioral concerns. WebProven effective in reducing or eliminating urinary incontinence. Some animals show no response. Schedule, update or cancel anytime, Reliable You can post now and register later. Stay current with the latest techniques and information sign up below to start your FREE Todays Veterinary Practice subscription today. 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It is not labeled for use in dogs weighing less than 10 pounds.10 Owing to a lack of safety and efficacy studies, using Proin ER tablets and Proin chewable tablets interchangeably is not recommended, nor is the use of Proin in pregnant or lactating animals.10. *If your pet is in need of urgent or emergency care, contact your pet's veterinarian immediately. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. That is encouraging. Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. Beisland HO, Fossberg E, Moer A, Sander S. Urethral sphincteric insufficiency in postmenopausal females: treatment with phenylpropanolamine and estriol separately and in combination. & Pomeroy, C.J. I am considering the compounding pharmacies as an option but it seems like the Incurin may be ok after all. & Barr, F.J. (1998) Ultrasonographic assessment of bladder neck mobility in continent bitches and bitches with urinary incontinence attributable to urethral sphincter mechanism incompetence. Similar results have been obtained with urethropexy (White 2001). Please enable JavaScript in order to continue using our website. The congenital condition is often associated with gross prostatic/pelvic urethral deformity and is unlikely to be successfully treated. Journal of Small Animal Practice 43, 493-496. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). So my girl has been incontinent since the day I brought her home. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. -- Ernest Hemmingway, http://www.leospetcare.com/incurin-estriol-is-not-the-same-as-ovaban-des/. (1985) Importance of urethral length, bladder-neck position and vestibulovaginal stenosis in sphincter mechanism incompetence in the incontinent bitch. Copyright 2023 PetMed Express, Inc. All Rights Reserved. 1988;32(2):273-280. Diethylstilbestrol (DES) is a commonly used synthetic, long acting estrogen, but it is not labeled for use in animals and is only available as a compounded product. My vet suggested DES for Passion but I'm not thrilled about adding another drug. in dogs having had the ovaries and uterus removed surgically). Sympathomimetics (Ephedrine, Epinephrine), Drugs for high blood pressure meds (Reserpine), Anesthetics (Isoflurane, Desflurane, Sevoflurane), Monoamine oxidase inhibitors or MAOIs (Anipryl). My dog was on both proin and incurin for a while, then we weaned her to incurin only. All rights reserved. A Guide to Aspirin for Dogs Dosage & More! So Incurin vs DES? Hanson KR, Ware WA. All dogs should receive an initial dose of 2 mg (two 1-mg tablets) orally once per day for a minimum of 14 days. Your thoughts/comments/experience would be greatly appreciated! Incurin for Dogs. April 1, 2019. fda.gov/animal-veterinary/cvm-updates/fda-approves-proin-er-tablets-controlling-urinary-incontinence-dogs, 6. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. J. small Anim. Overview Incurin is a veterinary medicine used for the treatment of hormone-dependent urinary incontinence resulting from sphincter mechanism incompetence (SMI) in ovariohysterectomised bitches (i.e. The exact abnormality leading to urethral sphincter mechanism incompetence and the region of the urethra in which it occurs are unknown. Forsee KM, Davis GJ, Mouat EE, et al. Proin chewable tablets. Performance & security by Cloudflare. Association of sympathomimetic drugs with malformations. (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. 9. In the authors experience, dogs affected with USMI that do not respond to phenylpropanolamine may respond to estriol or vice versa, and in some cases combination therapy is warranted. It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. Anybody can detect what this is on a dog? I also think she is less agitated and resting better. The vet will determine the dogs usual dose. Manufacturer-reported side effects include weight loss of >5%, vomiting, hypertension, anorexia, proteinuria, and anxiety/behavior change, including aggression.4 In the authors experience, therapy with estrogen-based products, such as estriol (Incurin; Merck Animal Health, merck-animal-health-usa.com), is preferable for patients with known behavioral concerns. We'd make sure she did her business before we'd leave but no matter what, she'd pee and poop while we were gone. Gilbert-Barness E, Drut RM. Looks like it was approved in March 2000. PRN Pharmacal. As in the bitch, the condition can occur as either a congenital or acquired condition. On both medications - not a single drop. That will teach you to keep your mouth shut." Reddit and its partners use cookies and similar technologies to provide you with a better experience. 2006;67(5):901-908. Maybe you could try it. How can you help your dog to be as healthy as possible? 2 J Small Anim Pract. I do like that the DES can be given less frequently than the Incurin but it seems that both are low dose which is good. Accessed. 5. The recommended labeled dose for Proin is 2 mg/kg PO q12h, to be dosed to the nearest half-tablet. In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase.4 Similarly, short-term dosing of phenylpropanolamine at 10 the recommended dose for 21 days resulted in hypertension, bradycardia, vomiting, leukocytosis, thrombocytosis, and elevations in ALT. Power, S.C., Eggleton, K.E., Aaron, A.J., Holt, P.E. 2. Proin chewable tablets were first approved by the FDA in 2011, and an extended-release formulation, Proin ER, was approved in 2019.4-6 In Europe and Canada a liquid formulation of phenylpropanolamine, Propalin (Vetoquinol, vetoquinol.ca), is available. It's an estrogen supplement similar to DES, but shorter acting so it has to be given daily. is an adrenergic agent that activates the adrenal receptors, similar mechanism of action like epinephrine and norepinephrine. While not reported in companion animal species, the use of sympathomimetic drugs, including phenylpropanolamine, has been associated with birth defects in people, rabbits, and chickens. 8. Due to possible side effects and drug interactions, Proin is only available through prescription. Am. The caudal bladder position in affected dogs is associated with the shorter urethral length and also the fact that the bladder moves caudally when a bitch moves from a standing to a relaxed recumbent position. If you are going to pursue looking for DES Wedgewood Compounding Pharmacy has made it up for our clinic recently-made it into a chicken flavored chewable tablet. Incurin is contraindicated in dogs showing polyuria secondary to polydipsia, or in pregnant dogs. Incurin contains the active substance estriol. The veterinarian will prescribe the strength that best fits your dogs size and needs. 2002;43(11):493-496. Were sorry, but our website doesnt work properly without JavaScript enabled. Sounds like your vet was having you give Incurin at the DES frequency. Short receptor binding time limits estrogen-related side effects. IMO routine blood pressures are a lacking You should always consult your own veterinarian for specific advice concerning the treatment of your pet. It is a multi-factorial problem and a variety of factors are known or suspected to contribute to its clinical manifestation of urinary incontinence. 6. Drugs used in it's management include androgens, oestrogens and alpha-adrenergics. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. 2010;184(2):201-207. ), is available. , but the issue is not confirmed in pets. While we provide information resources and canine education, the content here is not a substitute for veterinary guidance. We have called several vets around the area (I know they would want to do their own tests) and they all seem to have an outright policy against prescribing both. Madison, NJ: Intervet Inc.; 2011. Formulations that are no longer commercially available include Uriflex-PT, Uricon, Cystolamine, and Proin Drops. Since no true bladder neck sphincter exists in the bitch and continence is maintained by a complex mechanism of interacting factors, the term "urethral sphincter mechanism incompetence" has been used to describe a weakness of the urinary sphincter. (1996) Urethral sphincter mechanism incompetence in male dogs: a retrospective analysis of 54 cases. She gradually started leaking more over the last year. Vet. WebIncurin Tablets vs. Proin ER Comparison | PetMeds. Dr. Snell is a third-year internal medicine resident at the Ohio State University College of Veterinary Medicine. Proin is an FDA-approved drug for dogs that cannot hold pee as a result of urethral sphincter hypotonus. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. WebThe proin helped reduce the leaking but never fully stopped it. Create an account to follow your favorite communities and start taking part in conversations. 10. U.S. Food and Drug Administration Center for Veterinary Medicine. And now we have discovered that it has become very difficult to obtain this drug anymore. For additional information, please see theproduct label. with Rainey, the DES was fine with all the other stuff she was on but she was on it for a long time before all the other stuff cropped up. same with Rainey, woke up to a soaking wet bed got her in right after and they started the DES. Two new products are now available for veterinarians working to control urinary incontinence in canines. Please enable JavaScript in order to continue using our website. Your link has been automatically embedded. Holt,P.E .&Thrusfield,M.V. Hussain MA, Aungst BJ, Lam G, Shefter E. Phenylpropanolamine pharmacokinetics in dogs after intravenous, oral, and oral controlled-release doses. 10. 133, 177-180. Worked great. If you buy something from a link on our site, we may earn a commision. Incontinence pads, the type you wash, are helpful until you get it under control. It is unlikely, therefore, that anyone form of treatment alone will cure 100% of cases in the long-term. Is there a big difference between the two in how an old girlie will respond to it? 14F Dog drinking more and urinating frequently - why is How many dogs do you see who are over 18 years old? Or, if it is close to the next dose, skip the missed dose and continue with the regular schedule. The proin helped reduce the leaking but never fully stopped it. University of Bristol, Department of Clinical Veterinary ScienceLangford, Bristol, UK. Each Proin tablet is scored for a more precise dose calculation and features an enticing liver flavor for simple administration. We also bought puppy pee pads to lay under her in bed. Dr. Byron is a clinical professor in the department of veterinary clinical sciences at the Ohio State University (OSU) College of Veterinary Medicine. The symptoms of Proin toxicity are high blood pressure, abnormal heart rate, hyperexcitability, dilated pupils, tremors, and seizures. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%). Prior to its discontinuation in humans, combined therapy with phenylpropanolamine and estrogen derivatives was found to be synergistic, with increases in maximum urethral closure and reductions in leakage episodes. Rec. This is a sub for professional veterinary advice, and as such we follow strict rules for participating. 15. Our dog is 14 and was inconstant in her sleep. Clark JH, Hardin JW, McCormack SA. Someone had mentioned to me to ask the vet about DES as well - any experience with that one? Urodynamic and morphologic changes in the lower portion of the urogenital tract after administration of estriol alone and in combination with phenylpropanolamine in sexually intact and spayed female dogs. She started leaking urine when would lay down about 3 years ago. Proin (PRN Pharmacal, prnpharmacal.com) is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. Plumb DC. Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. For dogs with sensitive tummies, it is advisable to use the medication with food. Were sorry, but our website doesnt work properly without JavaScript enabled. Schedule, update or cancel anytime, Reliable In comparison with the bitch, the condition is less likely to respond to medical therapy. In addition to hypertension, dogs in the 3 and 5 manufacturer safety dosing groups were found to have significant elevations in platelet counts, alanine aminotransferase (ALT), and lactate dehydrogenase. 1. The proportion of dogs achieving treatment success was statistically significantly greater (p = 0.0038) in the group treated with INCURIN Tablets (66%) than Schweiz Arch Tierheilkd. Attempts have been made to relocate the intrapelvic bladder neck to an intra-abdominal position. The recommended dose of Proin ER is 2 to 4mg/kg PO q24h (to be given with food).10 Proin ER is available in 18-, 38-, 74-, and 145-mg tablets. Approximately half of affected bitches become continent following their first oestrus and should thus not be spayed earlier! The introduction of urethral pressure profilometry as an investigative aid in the bitch has allowed confirmation of the belief that poor urethral tone is implicated in urinary incontinence due to sphincter mechanism incompetence. Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog. Arnold S. Urinary incontinence in castrated bitches. I asked if peeing hurts her (medically) and he said no, just her pride. Special stock for AutoShip customers. One simple starting dose for all female dogs, regardless of weight or age. Oestrogens are contra-indicated in juvenile bitches with this condition because of possible adverse 'feedback' effects on the pituitary but alpha-adrenergics such as phenylpropanolamine could be used, pending oestrus. Byron JK, March PA, Chew DJ, DiBartola SP. Clark JH, Markaverich BM. My only reservation is that the Incurin is new and they do not know the long term effects just yet. 18. Accessed Kim and Bruce- with Rick (Rick Roufus 6/30/16) and missing my sweet greyhound Angels Rainey (LG's Rainey 10/4/2000 - 3/8/2011), Anubis (RJ's Saint Nick 12/25/2001 - 9/12/12) and Zeke (Hey Who Whiz It 4/6/2009 - 7/20/2020) and Larry (PTL Laroach 2/24/2007 - 8/2/2020) -- and Chester (Lab) (8/31/1990 - 5/3/2005), Captain (Schipperke) (10/12/1992 - 6/13/2005) and Remy (GSP) (?/?/1998 - 1/6/2005) at the bridge"Always do sober what you said you'd do drunk. Please also check the FAQ to see whether your question is answered there. I have seen online posts that both can be used at the same time as they work/target a dogs body differently but I cant find a vet that will do both. PRN Pharmacal. J Vet Intern Med. Dogs on meds with known drug interactions. The active ingredient Phenylpropanolamine (PPA) can be found in human formulations (Proin, Uriflex-PT Propalin, Cystolamine, Uricon), which in veterinary medicine are used off-label. ADVERSE REACTIONS: Mild, oestrogenic effects such as swollen vulva, swollen teats and/or attractiveness for males have been observed at the high dose of 2 mg. Also, do you know why it may be safer than DES? While every effort has been made to accurately represent the qualities and characteristics of each product, which for the most part were taken directly from the websites of the manufacturers, we are not responsible for any errors. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. Hanson KR, Ware WA. So, we asked our vet about trying DES. NADA 141-324. In general practice, therefore, the diagnosis is usually made on the basis of the breed, history and by the elimination of other possible diagnoses using imaging and laboratory techniques. FDA approves PROIN ER tablets for controlling urinary incontinence in dogs. Please be aware that estriol and phenylpropanolamine products should not be imported from other countries for use in animals. Vet. OP, your post has NOT been removed. Thank you. You could see a positive change in the dogs mood - perfect. Compare Incurin Tablets vs. Proin ER with a detailed product breakdown. 1. The author believes that cystopexy is contraindicated in these cases since it may result in detrusor instability, a further cause of urinary incontinence! After urinary incontinence is controlled, the lowest effective daily dose of Incurin should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. 39, 364-372. In dogs referred for the investigation of urinary incontinence, urethral sphincter mechanism incompetence is the commonest diagnosis made in adults and is second only to ureteral ectopia in juveniles, particularly in females. Blessed is the person who has earned the love of an old dog. 16. Two weeks and no adverse side effects. Phenylpropanolamine is a sympathomimetic amine that indirectly stimulates the 1 adrenergic receptors (and, to a lesser extent, -receptors) by causing release of norepinephrine, leading to constriction of the smooth muscle internal urethral sphincter.7,8 It is also thought to prolong its effect by inhibiting norepinephrine reuptake at the synaptic junction.7 Phenylpropanolamine may have decreased efficacy in patients on long-term therapy owing to either depletion of norepinephrine stores or desensitization of the -adrenergic receptors.7-9, The recommended labeled dose for Proin is 2 mg/kg PO q12h, to be dosed to the nearest half-tablet.6 Proin is commercially available in 25-, 50-, and 75-mg tablets.
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